Study Finds Hope in Treating Alzheimer’s With Wine Polyphenol

A new study has found encouraging results treating lab rats suffering from Alzheimer’s disease with polyphenols derived from red wine. The research is important because it’s a rare case where the wine compounds worked outside the petri dish. In the last five years, medical research has focused on wine polyphenols as a potential preventative for cognitive decline, but there has been little success with animal tests. This new study, from Mount Sinai in New York, comes one step closer to making such therapy a reality.
In lab conditions, polyphenols have broken down amyloid-beta plaques, which clog up the brain’s pathways in Alzheimer’s. In rodent testing, however, it becomes more of a challenge. Previous research finds that red wine-based supplements are often digested in the intestine, moved to the liver and then metabolized without great benefits. In order to create a clinical product for the body to absorb, a biosynthetic polyphenol would need to be ingested orally, nasally or subcutaneously to enter the bloodstream and travel to the brain.
There are other complications. As head researcher Dr. Giulio Pasinetti, a neurologist and geriatric researcher at Mount Sinai, points out, grapes from California are different than grapes from Greece. Red wine can contain polyphenols with very different chemical structures. Finding the best red wine molecule combination to direct toward human testing can be hit and miss. “It’s a relatively new field, the focus on grapes in nutraceuticals, and it is so very complicated,” Pasinetti told Wine Spectator. “The big problem is that the answers appear to be somewhere in red wine, but commercially available simulations, like grape powders, are not nearly as powerful.”
For this study, reported in a recent issue of the Journal of Neuroscience, the Mount Sinai researchers administered several doses of red wine polyphenols catechin and epicatechin to lab rats. They found when they altered the chemical structure from a polymer to a more simple monomer, the polyphenols accumulated in the brain. The red wine compounds were administered in drinking water, which means they were absorbed early in the digestive process.
It is the first time these chemicals were found in the brain, suggesting a possible preventative role, Pasinetti believes. Rats on the monomer combination not only showed fewer symptoms of Alzheimer’s, but also appeared to be more intelligent in several tests.
Pasinetti admitted that developing a possible therapy for people suffering from Alzheimer’s or other cognitive diseases will take time. But Mount Sinai is using the results toward its clinical research into aging and red wine consumption. So far, the researchers have not found an adequate substitute for the responsible consumption of red wine. And there are, from time to time, setbacks in the research that can delay the results. “Nature is unpredictable,” Passinetti said. “Sometimes you can end up going in the wrong direction.”

http://www.winespectator.com/webfeature/show/id/46786

Clark Wine Center was built in 2003 by Hong Kong-based Yats International Leisure Philippines to become the largest wine shop in Philippines supplying Asia’s wine lovers with fine vintage wines at attractive prices. Today, this wine shop in Clark Philippines offers over 2000 selections of fine wines from all major wine regions in the world. As a leading wine supplier in Philippines, Pampanga’s Clark Wine Center offers an incomparable breadth of vintages, wines from back vintages spanning over 50 years. Clark Wine Center is located in Pampanga Clark Freeport Zone adjacent to Angeles City, just 25 minutes from Subic and 45 minutes from Manila.

Things to do in Clark Philippines and Pampanga: do a little wine shopping at the famous wine shop outside of Manila called Clark Wine Center. One of the favorite places to visit in Pampanga Clark Freeport is the white building along M A Roxas highway of Clark which houses over 2000 selections of fine vintage wines. The Clark Wine Center is one of the places to visit, a tourist spot and a good shopping place for those staying in Angeles City, Subic or Clark Pampanga. It is lauded by food and wine lovers in Manila, Subic and Pampanga as the best wine shop outside Manila as well as a good place to buy wine in Pampanga.

Residents of Pampanga Angeles City, Subic, Tarlac and Clark Philippines know of this wine shop as one of the best places in Clark, a good night out place and simply the best place to hang out, enjoy some good wine with cheese on the roof deck with good atmosphere, or just relax and unwind with friends and family in a cool place. This wine shop in Clark Pampanga is recognized by many to be one of the best places to buy fine vintage wine in the Philippines. Located near Mimosa Leisure Estate surrounded by golf courses, resorts and a casino, this well known wine shop is frequently visited for its good selection of wine not available in Manila or Subic. Clark Wine Center is open 7 days a week from 10am to 8pm. Private dinners, wine tastings and group gatherings can be organized by advanced reservation.

Foodies and wine lovers travel north from Manila to wine and dine at Philippines’ best fine dining restaurant in Pampanga Clark Freeport worth the 60-minutes drive for a memorable evening of good food with vintage wine at Yats Restaurant & Wine Bar. Most guests would stop by this famous wine shop called Clark Wine Center to bring home a few good bottles of fine vintage wine also. Other visitors may find the wine selections in some of the restaurants in Angeles City Pampanga to be less than interesting, so they stop by this wine shop near Angeles City Pampanga Clark Philippines, buy some good wines and bring these bottles of good vintage wines to the restaurants so they can enjoy the dinner.

Wines from Burgundy, Bordeaux, Rhone, Loire, Spain, Portugal, Germany, Austria, Alsace, USA, Australia, New Zealand, Italy, South Africa, Chile and Argentina etc. are well represented in this Clark Wine Shop which is lauded by wine and food lovers from Manila and tourists from abroad as the best place to buy wine in Pampanga.

This is one of the frequently visited places for wine lovers from Manila and Angeles City to buy wines in Pampanga.

http://www.ClarkWineCenter.com

Getting to this wine shop in Pampanga Angeles City Clark Freeport Zone Philippines from Manila
Getting to the Clark Wine Center wine shop from Manila is quite simple: after entering Clark Freeport from Dau and Angeles City, proceed straight along the main highway M A Roxas. Clark Wine Center is the stand-along white building on the right, at the corner A Bonifacio Ave. From the Clark International Airport DMIA, ask the taxi to drive towards the entrance of Clark going to Angeles City. From Mimosa, just proceed towards the exit of Clark and this wine shop is on the opposite side of the main road M A Roxas.

Best place to buy wine in Clark Pampanga outside Manila near Subic and Angeles City Philippines is Clark Wine Center.

Click here to contact Clark Wine Center in Clark Pampanga for inquiries and orders.

Yats Leisure Philippines

Clark Wine Center
Bldg 6460 Clark Observatory Building
Manuel A. Roxas Highway corner A Bonifacio Ave,
Angeles Clark Freeport Zone, Pampanga 2023

Tel: 0922-870-5173 0917-826-8790 (ask for Ana Fe)

Wine@Yats-International.com

YATS Wine Cellars
Manila Sales Office
3003C East Tower, Phil Stock Exchange Center,
Exchange Road, Ortigas Centger,
Metro Manila, Philippines 1605

Tel: (632) 637-5019 0917-540-3626 ask for Rea or Chay

Log on to this web site for more information about Yats Wine Cellars as the leading wine importer and wine supplier in the Philippines:

ats Wine Cellars Leading Wine Supplier in Philippines

Wedding couples looking for wedding reception venues and beach wedding venues can log on to this Philippines Wedding Venue web site for free information and assistance:

http://www.PhilippinesWeddingVenue.com

While in Clark, it might be a good idea to enjoy an evening of wine-and-dine in the fine dining Yats Restaurant and Wine Bar that features an award winning 2700-line wine list. Highly recommended fine dining restaurant in Manila for special occasion is Yats Restaurant & Wine Lounge located in the famous Mimosa Leisure Estate in Clark Pampanga. Situated near this popular restaurant in Clark is the Mimosa Golf Course as well as the Mimosa Clark Casino. This top rated restaurant near Angeles City Pampanga in Clark Philippines is frequently used for private parties and corporate functions such as board meetings and other gatherings. It is located in Mimosa Leisure Estate of Clark Freeport Zone. For more information, visit http://www.YatsRestaurant.com

YATS Leisure Philippines is a developer and operator of clubs, resorts and high-class restaurants and wine shops in Clark Angeles Philippines http://www.YatsLeisure.com

Looking for famous tourists spots, places to visit and see, relax and unwind in Clark, Pampanga, Philippines? You may want to check out these sites also:

http://www.LondonPubClark.com

Besides good restaurants to wine and dine near Manila, Subic or in Angeles City Pampanga, Clark Philippines, those requiring assistance for hotel and resort bookings in Clark, Pampanga, Philippines may log on to http://www.HotelClarkPhilippines.com for more information and reservations.

The lifestyle in Clark Pampanga is quite unique. For more information about shopping, sports, golf, leisure, hotel accommodation, where to see and visit, what to do, where to wine and dine and good places to hang out, relax, have a drink with friends, child-friendly establishments, log on to
http://www.ClarkPhilippines.com

Wine lovers looking for a special bottle or something that is of great value and special discounts might log on to this web site to shop for fine vintage wines
http://www.YatsWineCellars.com

Those visitors who plan to relax and unwind in Angeles City, Subic, Pampanga, Clark Philippines might make an effort to book a room at the famous beach and lake resort Clearwater Resort & Country Club. This famous hotel in Clark Pampanga is frequently visited by families with children looking for a good place in Clark to see, a good holiday destination for the family to relax and unwind in the beautiful outdoor facilities. For more information, log on to
www.ClearwaterPhilippines.com

Buy wine in Manila, Metro Manila, Philippines at good wine shops and boutique wine stores that offer good selection of good vintage wines at all price points. Good white wines that available at the wine shops in Manila and Pampanga include Puligny Montrachet, Chassagne Montrachet, Pouilly Fuisse, Corton Charlemagne, Montrachet, Batard Montrachet and Beaune. Manila wine and food lovers looking for things to do in Pampanga and Manila can consider attending one of these wine events. Leading Philippines wine supplier and wine importer Yats Wine Cellars frequently hold public wine tasting in Clark, Pampanga and Manila. Even beginners can have a lot of fun attending these public wine tastings held by Yats. Participants enjoy good wine, learn some more about fine vintage wines and meet new friends during these wine tasting events of Yats Wine Cellars held in Manila and Pampanga.
Buy wine in Cebu, Philippines at good wine shops and boutique wine stores that offer good selection of good vintage wines at all price points.

Those looking for good wine gifts to send to friends and loved ones in the Philippines can now order special wine baskets from Yats Wine Cellars. Wines for giveaways can also be ordered from this wine supplier in Philippines. Delivery can be arranged with a courier service to practically everywhere in the Philippines. Wine baskets cost php3000 up. What makes Yats Wine Cellars’ wine gift baskets so special is that the wines are not seen anywhere else in Manila. This makes the gift special and exclusive.

Manila wine and food lovers looking for things to do in Pampanga and Manila can consider attending one of these wine events. The best way to learn more about wine in the Philippines is to attend public wine tasting events that have no sponsors. These wine tasting events held by Yats are non-commercial. Yats Wine Cellars does not promote a specific winery, producer or a brand. These wine tastings and wine dinners held in Manila and Pampanga are all designed to let wine lovers explore more interesting aspects of wine.