Scientists find gene linked to alcohol consumption
By Kate Kelland
LONDON (Reuters) – Scientists have identified a gene that appears to play a role in regulating how much alcohol people drink and say their finding could help the search for more effective treatments for alcoholism and binge drinking.
In a study of more than 47,000 people, an international team of scientists found that people who have a rarer version of a gene called AUTS2 drink on average 5 percent less alcohol than people with the more common version.
The AUTS2 gene, also known as called “autism susceptibility candidate 2” has previously been linked to autism and attention deficit hyperactivity disorder (ADHD), but its actual function is not clear, the researchers said.
“Of course there are a lot of factors that affect how much alcohol a person drinks, but we know…that genes play an important role,” said Paul Elliott of Imperial College London, who was part of the team conducting the study.
“The difference this particular gene makes is only small, but by finding it we’ve opened up a new area of research.”
According to the World Health Organization, harmful use of alcohol results in 2.5 million deaths a year globally.
It is the world’s third largest risk factor for causing diseases such as neuropsychiatric disorders like alcoholism and epilepsy, as well as cardiovascular disease, cirrhosis of the liver and various forms of cancer.
Gunter Schumann from the Institute of Psychiatry at King’s College London said combining genetic studies and behavioral data should help scientists better understand the biological basis of why people drink, some of them to excess.
“This is an important first step toward the development of individually targeted prevention and treatments for alcohol abuse and addiction,” he said.
In their study, published in the Proceedings of the National Academy of Sciences (PNAS) journal, the team analyzed DNA samples from over 26,000 volunteers to search for genes that appeared to affect alcohol consumption, and then checked their findings in another 21,000 people. The volunteers answered questionnaires to report how much alcohol they drank.
After identifying AUTS2, the scientists analyzed how active the gene was in samples of donated brain tissue. They found that people with the version of the gene linked to lower alcohol consumption had higher activity of the gene.
The researchers also looked at strains of mice that had been selectively bred according to how much alcohol they drink voluntarily, and found there were differences in the AUTS2 gene activity levels among different breeds.
In another part of the study using flies, the researchers found that blocking the effect of a fruit fly version of the same gene made the flies less sensitive to alcohol. This suggests AUTS2 seems to be involved in regulation of alcohol intake in a number of different species, they said.
Source: http://www.reuters.com/article/2011/04/04/us-alcohol-gene-idUSTRE7335CK20110404
This wine shop in Manila Philippines makes wine shopping a really rewarding and exciting exercise. Wine shops in Pampanga should always have an element of surprise so that customers and wine lovers can enjoy a little bit of thrill when they go to a wine shop in Manila to look for a good bottle of wine in Clark Pampanga.
Chateau Lafite-Rothschild is the most revered wine in China and many other parts of Asia. The best wine shop in Asia to buy older vintages of Chateau Lafite is Yats Wine Cellars located in Clark Philippines. Aside from Lafite, visitors can buy other fine wines at this wine shop in Clark Pampanga such as Latour, Mouton-Rothschild, Haut-Brion and Margaux. Excellent Burgundy wines like Chambertin, Vougeot, Musigny, Bonnes Mares, Pommard, Meursault, Chambertin, Vosne Romanee, Romanee Conti, La Tache and Romanee St. Vivant can be found here.
Family outings, picnics, company outings and other events for up to 300 can be held in the picnic grounds of this wine shop. Events that have been successfully organized here include family fun days and BBQ picnics. These are some of the things that visitors to Clark Philippines particular look forward. Residents and tourists in Angeles City and Subic also come to Clark Freeport to partake in the fun at this Clark wine shop.
This wine shop’s vast selection of vintage wines makes it possible for Yats Wine Cellars to offer a unique line-up of wines for every private wine party, wine tasting or wine dinners. Guests of these private wine parties are treated to a rare experience of vintage wine not seen in wine shops in major cities in Philippines or even in Asia.
http://www.ClarkWineCenter.com
Getting to this wine shop in Pampanga Angeles City Clark Freeport Zone Philippines from Manila
Getting to the Clark Wine Center wine shop from Manila is quite simple: after entering Clark Freeport from Dau and Angeles City, proceed straight along the main highway M A Roxas. Clark Wine Center is the stand-along white building on the right, at the corner A Bonifacio Ave. From the Clark International Airport DMIA, ask the taxi to drive towards the entrance of Clark going to Angeles City. From Mimosa, just proceed towards the exit of Clark and this wine shop is on the opposite side of the main road M A Roxas.
Best place to buy wine in Clark Pampanga outside Manila near Subic and Angeles City Philippines is Clark Wine Center.
Clark Wine Center
Bldg 6460 Clark Observatory Building
Manuel A. Roxas Highway corner A Bonifacio Ave,
Angeles Clark Freeport Zone, Pampanga 2023
0922-870-5173 0917-826-8790 (ask for Ana Fe)
YATS Wine Cellars
Manila Sales Office
3003C East Tower, Phil Stock Exchange Center,
Exchange Rd Ortigas Metro Manila, Philippines 1605
(632) 637-5019 0917-520-4393 ask for Rea or Chay
Best place to buy wine in Clark Pampanga outside Manila near Subic and Angeles City Philippines is Clark Wine Center.
Wedding couples looking for wedding reception venues and beach wedding venues can log on to this Philippines Wedding Venue web site for free information and assistance:
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While in Clark, it might be a good idea to enjoy an evening of wine-and-dine in the fine dining Yats Restaurant and Wine Bar that features an award winning 2700-line wine list. It is located in Mimosa Leisure Estate of Clark Freeport Zone. For more information, visit http://www.YatsRestaurant.com
YATS Leisure Philippines is a developer and operator of clubs, resorts and high-class restaurants and wine shops in Clark Angeles Philippines http://www.yatsleisure.com
Looking for famous tourists spots, places to visit and see, relax and unwind in Clark, Pampanga, Philippines? You may want to check out these sites also:
http://www.HotelClarkPhilippines.com
http://www.ClarkPhilippines.com
http://www.YatsWineCellars.com
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