Alcohol may permanently damage DNA, causing cancer
Washington: Scientists have discovered that breakdown of alcohol by the body forms a substance that can damage DNA dramatically and increase chances of cancer, with people of Asian descent at a greater risk.
Researchers from the University of Minnesota found that when human body breaks down, or metabolises, the alcohol in beer, wine and hard liquor, one of the substances formed is acetaldehyde, a substance with a chemical backbone that resembles formaldehyde, a known human carcinogen.
Scientists also have known from laboratory experiments that acetaldehyde can cause DNA damage, trigger chromosomal abnormalities in cell cultures and act as an animal carcinogen.
“We now have the first evidence from living human volunteers that acetaldehyde formed after alcohol consumption damages DNA dramatically,” Silvia Balbo, who led the study, said.
“Acetaldehyde attaches to DNA in humans – to the genetic material that makes up genes – in a way that results in the formation of a ‘DNA adduct.’ It’s acetaldehyde that latches onto DNA and interferes with DNA activity in a way linked to an increased risk of cancer,” Balbo added.
“Alcohol, a lifestyle carcinogen, is metabolised into acetaldehyde in the mouth, and acetaldehyde is forming DNA adducts, which are known major players in carcinogenesis,” Balbo said in a statement.
Balbo pointed out that people have a highly effective natural repair mechanism for correcting the damage from DNA adducts. Most people thus are unlikely to develop cancer from social drinking, although alcohol is associated with a risk of other health problems and accidents.
In addition, most people have an enzyme called alcohol dehydrogenase, which quickly converts acetaldehyde to acetate, a relatively harmless substance.
However, about 30 per cent of people of Asian descent- almost 1.6 billion people- have a variant of the alcohol dehydrogenase gene and are unable to metabolise alcohol to acetate.
That genetic variant results in an elevated risk of esophageal cancer from alcohol drinking. Native Americans and native Alaskans have a deficiency in the production of that same enzyme.
To test the hypothesis that acetaldehyde causes DNA adducts to form in humans, Balbo and colleagues gave 10 volunteers increasing doses of vodka (comparable to one, two and three drinks) once a week for three weeks.
They found that levels of a key DNA adduct increased up to 100-fold in the subjects’ oral cells within hours after each dose, then declined about 24 hours later. Adduct levels in blood cells also rose.
The study was presented at the 244th National Meeting & Exposition of the American Chemical Society.
Buy wine in Pampanga, Philippines at good wine shops and boutique wine stores that offer good selection of good vintage wines at all price points. Wine lovers in Philippines can find good red wines in wine shops in Manila and Pampanga. Among the good selections of French red wines from Bordeaux are Chateau Gloria, Chateau Lafite, Chateau Margaux, Chateau Petrus, Chateau Lynch Bages, Chateau Latour, Chateau Mouton Rothschild, Chateau Cheval Blanc, Chateau Ausone, Chateau le Pin, Chateau Palmer, Chateau Pontet Canet, Chateau Carruades de Lafite, Chateau les Forts de Latour, Chateau Pichon Lalande. This makes it easy and convenient for wine lovers to buy wine in Manila. Manila wine and food lovers looking for things to do in Pampanga and Manila can consider attending one of these wine events. Leading Philippines wine supplier and wine importer Yats Wine Cellars frequently hold public wine tasting in Clark, Pampanga and Manila.
http://www.firstpost.com/fwire/alcohol-may-permanently-damage-dna-causing-cancer-427684.html
Clark Wine Center was built in 2003 by Hong Kong-based Yats International Leisure Philippines to become the largest wine shop in Philippines supplying Asia’s wine lovers with fine vintage wines at attractive prices. Today, this wine shop in Clark Philippines offers over 2000 selections of fine wines from all major wine regions in the world. As a leading wine supplier in Philippines, Pampanga’s Clark Wine Center offers an incomparable breadth of vintages, wines from back vintages spanning over 50 years. Clark Wine Center is located in Pampanga Clark Freeport Zone adjacent to Angeles City, just 25 minutes from Subic and 45 minutes from Manila.
Things to do in Clark Philippines and Pampanga: do a little wine shopping at the famous wine shop outside of Manila called Clark Wine Center. One of the favorite places to visit in Pampanga Clark Freeport is the white building along M A Roxas highway of Clark which houses over 2000 selections of fine vintage wines. The Clark Wine Center is one of the places to visit, a tourist spot and a good shopping place for those staying in Angeles City, Subic or Clark Pampanga. It is lauded by food and wine lovers in Manila, Subic and Pampanga as the best wine shop outside Manila as well as a good place to buy wine in Pampanga.
Residents of Pampanga Angeles City, Subic, Tarlac and Clark Philippines know of this wine shop as one of the best places in Clark, a good night out place and simply the best place to hang out, enjoy some good wine with cheese on the roof deck with good atmosphere, or just relax and unwind with friends and family in a cool place. This wine shop in Clark Pampanga is recognized by many to be one of the best places to buy fine vintage wine in the Philippines. Located near Mimosa Leisure Estate surrounded by golf courses, resorts and a casino, this well known wine shop is frequently visited for its good selection of wine not available in Manila or Subic. Clark Wine Center is open 7 days a week from 10am to 8pm. Private dinners, wine tastings and group gatherings can be organized by advanced reservation.
Foodies and wine lovers travel north from Manila to wine and dine at Philippines’ best fine dining restaurant in Pampanga Clark Freeport worth the 60-minutes drive for a memorable evening of good food with vintage wine at Yats Restaurant & Wine Bar. Most guests would stop by this famous wine shop called Clark Wine Center to bring home a few good bottles of fine vintage wine also. Other visitors may find the wine selections in some of the restaurants in Angeles City Pampanga to be less than interesting, so they stop by this wine shop near Angeles City Pampanga Clark Philippines, buy some good wines and bring these bottles of good vintage wines to the restaurants so they can enjoy the dinner.
Wines from Burgundy, Bordeaux, Rhone, Loire, Spain, Portugal, Germany, Austria, Alsace, USA, Australia, New Zealand, Italy, South Africa, Chile and Argentina etc. are well represented in this Clark Wine Shop which is lauded by wine and food lovers from Manila and tourists from abroad as the best place to buy wine in Pampanga.
This is one of the frequently visited places for wine lovers from Manila and Angeles City to buy wines in Pampanga.
http://www.ClarkWineCenter.com
Getting to this wine shop in Pampanga Angeles City Clark Freeport Zone Philippines from Manila
Getting to the Clark Wine Center wine shop from Manila is quite simple: after entering Clark Freeport from Dau and Angeles City, proceed straight along the main highway M A Roxas. Clark Wine Center is the stand-along white building on the right, at the corner A Bonifacio Ave. From the Clark International Airport DMIA, ask the taxi to drive towards the entrance of Clark going to Angeles City. From Mimosa, just proceed towards the exit of Clark and this wine shop is on the opposite side of the main road M A Roxas.
Best place to buy wine in Clark Pampanga outside Manila near Subic and Angeles City Philippines is Clark Wine Center.
Click here to contact Clark Wine Center in Clark Pampanga for inquiries and orders.
Yats Leisure Philippines
Clark Wine Center
Bldg 6460 Clark Observatory Building
Manuel A. Roxas Highway corner A Bonifacio Ave,
Angeles Clark Freeport Zone, Pampanga 2023
Tel: 0922-870-5173 0917-826-8790 (ask for Ana Fe)
Wine@Yats-International.com
YATS Wine Cellars
Manila Sales Office
3003C East Tower, Phil Stock Exchange Center,
Exchange Road, Ortigas Centger,
Metro Manila, Philippines 1605
Tel: (632) 637-5019 0917-540-3626 ask for Rea or Chay
Log on to this web site for more information about Yats Wine Cellars as the leading wine importer and wine supplier in the Philippines:
ats Wine Cellars Leading Wine Supplier in Philippines
Wedding couples looking for wedding reception venues and beach wedding venues can log on to this Philippines Wedding Venue web site for free information and assistance:
http://www.PhilippinesWeddingVenue.com
While in Clark, it might be a good idea to enjoy an evening of wine-and-dine in the fine dining Yats Restaurant and Wine Bar that features an award winning 2700-line wine list. Highly recommended fine dining restaurant in Manila for special occasion is Yats Restaurant & Wine Lounge located in the famous Mimosa Leisure Estate in Clark Pampanga. Situated near this popular restaurant in Clark is the Mimosa Golf Course as well as the Mimosa Clark Casino. This top rated restaurant near Angeles City Pampanga in Clark Philippines is frequently used for private parties and corporate functions such as board meetings and other gatherings. It is located in Mimosa Leisure Estate of Clark Freeport Zone. For more information, visit http://www.YatsRestaurant.com
YATS Leisure Philippines is a developer and operator of clubs, resorts and high-class restaurants and wine shops in Clark Angeles Philippines http://www.YatsLeisure.com
Looking for famous tourists spots, places to visit and see, relax and unwind in Clark, Pampanga, Philippines? You may want to check out these sites also:
Besides good restaurants to wine and dine near Manila, Subic or in Angeles City Pampanga, Clark Philippines, those requiring assistance for hotel and resort bookings in Clark, Pampanga, Philippines may log on to http://www.HotelClarkPhilippines.com for more information and reservations.
The lifestyle in Clark Pampanga is quite unique. For more information about shopping, sports, golf, leisure, hotel accommodation, where to see and visit, what to do, where to wine and dine and good places to hang out, relax, have a drink with friends, child-friendly establishments, log on to
http://www.ClarkPhilippines.com
Wine lovers looking for a special bottle or something that is of great value and special discounts might log on to this web site to shop for fine vintage wines
http://www.YatsWineCellars.com
Those visitors who plan to relax and unwind in Angeles City, Subic, Pampanga, Clark Philippines might make an effort to book a room at the famous beach and lake resort Clearwater Resort & Country Club. This famous hotel in Clark Pampanga is frequently visited by families with children looking for a good place in Clark to see, a good holiday destination for the family to relax and unwind in the beautiful outdoor facilities. For more information, log on to
www.ClearwaterPhilippines.com
TRAILER TWO
Tourists and residents of Manila travel out of town to the north on a short getaway look for the best place in Clark to buy some fine vintage wine to bring home after their holidays and vacations. Many find a top rated wine shop called Clark Wine Center to be an exciting place to do some shopping in Clark Pampanga. This famous wine shop is highly recommended for visitors going to Clark Pampanga to drink good wine, relax and unwind with friends and families. Clark Wine Center is also lauded by wine and food lovers from Manila and tourists from abroad as the best place to buy wine in Pampanga.
This frequently visited wine shop outside Manila is known by tourist and visitors to Pampanga, Angeles city, Subic and Clark Philippines as a cool place to hang out in Clark. Many attend the regular wine tasting held either outdoor on the roof deck or in indoor on the second floor above the wine shop. The place has good atmosphere for a private wine tasting party or a small night out gatherings for business or social event. Clark Wine Center is lauded by food and wine lovers in Manila, Subic and Pampanga as the best wine shop outside Manila as well as a good place to buy wine in Pampanga.
Tourists and visitors staying in Angeles City, Tarlac, Baguio, Subic and Pampanga sometimes wonder what are the things to do in Clark Philippines and Pampanga? Frequent visitors to Pampanga discover that it is fun to do a little wine shopping at the famous wine shop outside of Manila called Clark Wine Center. One of the favorite places to visit in Pampanga Clark Freeport is the white building along M A Roxas highway of Clark which houses over 2000 selections of fine vintage wines. The Clark Wine Center is one of the places to visit, a tourist spot and a good shopping place for those staying in Angeles City, Subic or Clark Pampanga.
Leading Philippines Wine Supplier Yats Wine Cellars, leading supplier of fine wines in Philippines with outlets in Angeles City, Subic Freeport and Manila Philippines has been not only a wine shop for fine wines covering all major wine regions but also a source of reliable and useful information about wine, wine appreciation, wine accessories, wine and health, food and wine pairing and all other matters relating to wine and its appreciation. This Philippines Clark Freeport based Wine Supplier and Wine Shop frequently holds public wine tasting events in Pampanga Clark Freeport Zone, Angeles City, Subic Bay area, Makati, Fort Bonifacio and other areas in Philippines capital city Manila. Private Wine events such as private wine tasting and private wine dinners are also designed and organized for private clientele for their wine loving guests.
Log on to this web site for more information about Yats Wine Cellars as the leading wine importer and wine supplier in the Philippines:
ats Wine Cellars Leading Wine Supplier in Philippines
Wine Catering is a unique product of Yats Wine Cellars, created back in 2005 in response to a growing demand for private wine parties in Manila, Cebu, Subic, Angeles Clark Philippines.
Chateau Lafite-Rothschild is the most revered wine in China and many other parts of Asia. The best wine shop in Asia to buy older vintages of Chateau Lafite is Yats Wine Cellars located in Clark Philippines. Aside from Lafite, visitors can buy other fine wines at this wine shop in Clark Pampanga such as Latour, Mouton-Rothschild, Haut-Brion and Margaux. Excellent Burgundy wines like Chambertin, Vougeot, Musigny, Bonnes Mares, Pommard, Meursault, Chambertin, Vosne Romanee, Romanee Conti, La Tache and Romanee St. Vivant can be found here.
Yats Wine Cellars can be reached at their Clark Wine Center Philippines wine shop located on the main highway M A Roxas of Pampanga Clark Freeport Zone or their sales office in Ortigas Centre, Metro Manila. Here is the contact information:
http://www.ClarkWineCenter.com
Getting to this wine shop in Pampanga Angeles City Clark Freeport Zone Philippines from Manila
Getting to the Clark Wine Center wine shop from Manila is quite simple: after entering Clark Freeport from Dau and Angeles City, proceed straight along the main highway M A Roxas. Clark Wine Center is the stand-along white building on the right, at the corner A Bonifacio Ave. From the Clark International Airport DMIA, ask the taxi to drive towards the entrance of Clark going to Angeles City. From Mimosa, just proceed towards the exit of Clark and this wine shop is on the opposite side of the main road M A Roxas.
Best place to buy wine in Clark Pampanga outside Manila near Subic and Angeles City Philippines is Clark Wine Center.
Click here to contact Clark Wine Center in Clark Pampanga for inquiries and orders.
Clark Wine Center
Yats Leisure Philippines
Bldg 6460 Clark Observatory Building
Manuel A. Roxas Highway corner A Bonifacio Ave,
Angeles Clark Freeport Zone, Pampanga 2023
0922-870-5173 0917-826-8790 (ask for Ana Fe)
Wine@Yats-International.com
YATS Wine Cellars
Manila Sales Office
3003C East Tower, Phil Stock Exchange Center,
Exchange Rd Ortigas Metro Manila, Philippines 1605
(632) 637-5019 0917-520-4393 ask for Rea or Chay
Log on to this web site for more information about Yats Wine Cellars as the leading wine importer and wine supplier in the Philippines:
ats Wine Cellars Leading Wine Supplier in Philippines
Wedding couples looking for wedding reception venues and beach wedding venues can log on to this Philippines Wedding Venue web site for free information and assistance:
http://www.PhilippinesWeddingVenue.com
While in Clark, it might be a good idea to enjoy an evening of wine-and-dine in the fine dining Yats Restaurant and Wine Bar that features an award winning 2700-line wine list. Highly recommended fine dining restaurant in Manila for special occasion is Yats Restaurant & Wine Lounge located in the famous Mimosa Leisure Estate in Clark Pampanga. Situated near this popular restaurant in Clark is the Mimosa Golf Course as well as the Mimosa Clark Casino. This top rated restaurant near Angeles City Pampanga in Clark Philippines is frequently used for private parties and corporate functions such as board meetings and other gatherings. It is located in Mimosa Leisure Estate of Clark Freeport Zone. For more information, visit http://www.YatsRestaurant.com
YATS Leisure Philippines is a developer and operator of clubs, resorts and high-class restaurants and wine shops in Clark Angeles Philippines http://www.YatsLeisure.com
Looking for famous tourists spots, places to visit and see, relax and unwind in Clark, Pampanga, Philippines? You may want to check out these sites also:
Besides good restaurants to wine and dine near Manila, Subic or in Angeles City Pampanga, Clark Philippines, those requiring assistance for hotel and resort bookings in Clark, Pampanga, Philippines may log on to http://www.HotelClarkPhilippines.com for more information and reservations.
The lifestyle in Clark Pampanga is quite unique. For more information about shopping, sports, golf, leisure, hotel accommodation, where to see and visit, what to do, where to wine and dine and good places to hang out, relax, have a drink with friends, child-friendly establishments, log on to
http://www.ClarkPhilippines.com
Wine lovers looking for a special bottle or something that is of great value and special discounts might log on to this web site to shop for fine vintage wines
http://www.YatsWineCellars.com
Those visitors who plan to relax and unwind in Angeles City, Subic, Pampanga, Clark Philippines might make an effort to book a room at the famous beach and lake resort Clearwater Resort & Country Club. This famous hotel in Clark Pampanga is frequently visited by families with children looking for a good place in Clark to see, a good holiday destination for the family to relax and unwind in the beautiful outdoor facilities. For more information, log on to www.ClearwaterPhilippines.com
Buy wine gift baskets in Philippines from Yats Wine Cellars. Wine lovers in Philippines can find good wines from major wine regions around the world in wine shops in Manila and Pampanga. Among the good selections of fine vintage wines from Italy, Spain, Portugal, Germany, Austria and other parts of Europe. Rare vintage wines from Vega Sicilia, Biondi Santi, Sassicaia as well as the Ice wine from Germany can be found in good wine shops around Manila. This makes it easy and convenient for wine lovers to buy wine in Manila. If you are thinking of buying wines to give as gift in the Philippines, then contact Yats Wine Cellars now because they offer special vintage wines suitable as gift at all price points. Since most of these wines are not available in Manila, these wine gifts are excellent choices for corporate gifts as well as wine gifts for personal and social purposes. These can be wines or wine baskets.
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